![]() ![]() Bleeding in the gastrointestinal tract is common with this condition. A failing liver cannot make enough clotting factors, which help blood to clot. Too much fluid causes pressure to build up in your brain, which can lead to disorientation, severe mental confusion and seizures. Too much fluid in the brain (cerebral edema).ComplicationsĪcute liver failure often causes complications, including: Some cases of acute liver failure have no obvious cause. Extreme physical activity in a hot environment can trigger acute liver failure. Overwhelming infection (sepsis) and shock can severely reduce blood flow to the liver, causing liver failure. Cancer that either begins in or spreads to your liver can cause your liver to fail. Rare metabolic diseases, such as Wilson's disease and acute fatty liver of pregnancy, infrequently cause acute liver failure. Vascular diseases, such as Budd-Chiari syndrome, can cause blockages in the veins of the liver and lead to acute liver failure. Liver failure can be caused by autoimmune hepatitis - a disease in which your immune system attacks liver cells, causing inflammation and injury. It is an industrial chemical found in refrigerants and solvents for waxes, varnishes and other materials. Carbon tetrachloride is another toxin that can cause acute liver failure. Toxins that can cause acute liver failure include the poisonous wild mushroom Amanita phalloides, which is sometimes mistaken for one that is safe to eat. Other viruses that can cause acute liver failure include Epstein-Barr virus, cytomegalovirus and herpes simplex virus. Hepatitis A, hepatitis B and hepatitis E can cause acute liver failure. Herbal drugs and supplements, including kava, ephedra, skullcap and pennyroyal, have been linked to acute liver failure. Some prescription medications, including antibiotics, nonsteroidal anti-inflammatory drugs and anticonvulsants, can cause acute liver failure. Don't wait for the signs of liver failure. If you or someone you know has taken an overdose of acetaminophen, seek medical attention as quickly as possible. Acute liver failure can occur after one very large dose of acetaminophen, or after higher than recommended doses every day for several days. ![]() Outside of the United States, acetaminophen is known as paracetamol. Taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the United States. Potential causes include:Īcetaminophen overdose. Acute liver failure occurs when liver cells are damaged significantly and are no longer able to function. ![]()
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